Drug interactions
Ferric citrate + Gemifloxacin
Severity: Moderate
Ferric citrate and Gemifloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ferric citrate releases iron in the gut that can bind gemifloxacin and form poorly absorbed complexes. This lowers gemifloxacin absorption and may lead to subtherapeutic antibiotic levels and treatment failure.
What this interaction means in plain words
Ferric citrate and Gemifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ferric citrate belongs to Miscellaneous; Gemifloxacin belongs to Anti Bacterial.
Why it happens
Chelation of gemifloxacin by polyvalent iron cations in the gastrointestinal tract reduces its absorption.
What to do
Give gemifloxacin at least 3 hours before or 2 hours after ferric citrate. Monitor clinical response to the antibiotic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gemifloxacin
- Arsenic trioxide + Gemifloxacin Contraindicated
- Dofetilide + Gemifloxacin Contraindicated
- Gemifloxacin + Ibutilide Contraindicated
- Gemifloxacin + Pimozide Contraindicated
- Gemifloxacin + Thioridazine Contraindicated
- Gemifloxacin + Vandetanib Contraindicated
Other interactions of Ferric citrate
- Ciprofloxacin + Ferric citrate Moderate
- Deferiprone + Ferric citrate Moderate
- Doxycycline + Ferric citrate Moderate
- Ferric citrate + Levofloxacin Moderate
- Ferric citrate + Moxifloxacin Moderate
- Ferric citrate + Ofloxacin Moderate
Frequently asked questions
Can I take Ferric citrate with Gemifloxacin?
MediHelp rates the interaction as moderate. Ferric citrate and Gemifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ferric citrate releases iron in the gut that can bind gemifloxacin and form poorly absorbed complexes. This lowers gemifloxacin absorption and may lead to subtherapeutic antibiotic levels and treatment failure.
How serious is the interaction between Ferric citrate and Gemifloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give gemifloxacin at least 3 hours before or 2 hours after ferric citrate. Monitor clinical response to the antibiotic.
What other medicines interact with Gemifloxacin?
MediHelp also lists interactions of Gemifloxacin with, for example, Arsenic trioxide, Dofetilide, Ibutilide. The full list is on the Gemifloxacin page.
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