Drug interactions
Doxycycline + Ferric citrate
Severity: Moderate
Doxycycline and Ferric citrate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ferric iron binds doxycycline in the gut, reducing its absorption and potentially compromising antibiotic efficacy.
What this interaction means in plain words
Doxycycline and Ferric citrate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Doxycycline belongs to Anti Bacterial; Ferric citrate belongs to Miscellaneous.
Why it happens
Chelation of doxycycline by ferric iron in the gastrointestinal tract.
What to do
Give doxycycline at least 1 to 2 hours before ferric citrate, and monitor clinical response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Doxycycline and Ferric citrate, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Doxycycline
- Acitretin + Doxycycline Contraindicated
- Aminolevulinic acid + Doxycycline Major
- Cholera vaccine + Doxycycline Major
- Doxycycline + Isotretinoin Major
- Doxycycline + Methoxyflurane Major
- Doxycycline + Microbiota Major
Other interactions of Ferric citrate
- Ciprofloxacin + Ferric citrate Moderate
- Deferiprone + Ferric citrate Moderate
- Ferric citrate + Gemifloxacin Moderate
- Ferric citrate + Levofloxacin Moderate
- Ferric citrate + Moxifloxacin Moderate
- Ferric citrate + Ofloxacin Moderate
Frequently asked questions
Can I take Doxycycline with Ferric citrate?
MediHelp rates the interaction as moderate. Doxycycline and Ferric citrate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ferric iron binds doxycycline in the gut, reducing its absorption and potentially compromising antibiotic efficacy.
How serious is the interaction between Doxycycline and Ferric citrate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give doxycycline at least 1 to 2 hours before ferric citrate, and monitor clinical response.
What other medicines interact with Doxycycline?
MediHelp also lists interactions of Doxycycline with, for example, Acitretin, Aminolevulinic acid, Cholera vaccine. The full list is on the Doxycycline page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
