Drug interactions
Deferiprone + Magnesium hydroxide
Severity: Moderate
Deferiprone and Magnesium hydroxide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Deferiprone chelates polyvalent cations such as magnesium in the gut. Taken together, this can reduce deferiprone absorption and diminish its iron-chelating effect.
What this interaction means in plain words
Deferiprone and Magnesium hydroxide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deferiprone belongs to Miscellaneous; Magnesium hydroxide belongs to Gastrointestinal Tract.
Why it happens
Deferiprone forms chelate complexes with magnesium, reducing its absorption.
What to do
Take magnesium-containing antacids at least 4 hours apart from deferiprone. Monitor ferritin to confirm chelation efficacy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Magnesium hydroxide
Other interactions of Deferiprone
- Clozapine + Deferiprone Contraindicated
- Abemaciclib + Deferiprone Major
- Acalabrutinib + Deferiprone Major
- Ado-trastuzumab emtansine + Deferiprone Major
- Ado-trastuzumab + Deferiprone Major
- Aldesleukin + Deferiprone Major
Frequently asked questions
Can I take Deferiprone with Magnesium hydroxide?
MediHelp rates the interaction as moderate. Deferiprone and Magnesium hydroxide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Deferiprone chelates polyvalent cations such as magnesium in the gut. Taken together, this can reduce deferiprone absorption and diminish its iron-chelating effect.
How serious is the interaction between Deferiprone and Magnesium hydroxide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Take magnesium-containing antacids at least 4 hours apart from deferiprone. Monitor ferritin to confirm chelation efficacy.
What other medicines interact with Magnesium hydroxide?
MediHelp also lists interactions of Magnesium hydroxide with, for example, Ciprofloxacin, Dolutegravir, Gemifloxacin. The full list is on the Magnesium hydroxide page.
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