Drug interactions
Deferiprone + Magnesium oxide
Severity: Minor
Deferiprone and Magnesium oxide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Deferiprone is an iron chelator that can also bind polyvalent cations such as magnesium in the gut. Taking it with magnesium-containing antacids may reduce its absorption and weaken its iron-chelating effect.
What this interaction means in plain words
Deferiprone and Magnesium oxide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Deferiprone belongs to Miscellaneous; Magnesium oxide belongs to Gastrointestinal Tract.
Why it happens
Chelation of deferiprone by magnesium in the gastrointestinal tract reduces oral absorption.
What to do
Separate doses of deferiprone and magnesium oxide by at least 4 hours. Monitor serum ferritin if the two are used together regularly.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Deferiprone
- Clozapine + Deferiprone Contraindicated
- Abemaciclib + Deferiprone Major
- Acalabrutinib + Deferiprone Major
- Ado-trastuzumab emtansine + Deferiprone Major
- Ado-trastuzumab + Deferiprone Major
- Aldesleukin + Deferiprone Major
Other interactions of Magnesium oxide
- Chloroquine + Magnesium oxide Moderate
- Ciprofloxacin + Magnesium oxide Moderate
- Dolutegravir + Magnesium oxide Moderate
- Doxycycline + Magnesium oxide Moderate
- Eltrombopag + Magnesium oxide Moderate
- Gemifloxacin + Magnesium oxide Moderate
Frequently asked questions
Can I take Deferiprone with Magnesium oxide?
MediHelp rates the interaction as minor. Deferiprone and Magnesium oxide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Deferiprone is an iron chelator that can also bind polyvalent cations such as magnesium in the gut. Taking it with magnesium-containing antacids may reduce its absorption and weaken its iron-chelating effect.
How serious is the interaction between Deferiprone and Magnesium oxide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate doses of deferiprone and magnesium oxide by at least 4 hours. Monitor serum ferritin if the two are used together regularly.
What other medicines interact with Deferiprone?
MediHelp also lists interactions of Deferiprone with, for example, Clozapine, Abemaciclib, Acalabrutinib. The full list is on the Deferiprone page.
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