Drug interactions
Deferiprone + Ribociclib
Severity: Major
Deferiprone and Ribociclib: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ribociclib commonly causes dose-related neutropenia, and deferiprone can cause agranulocytosis. Combined use may increase the risk of severe neutropenia and infection.
What this interaction means in plain words
Deferiprone and Ribociclib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Deferiprone belongs to Miscellaneous; Ribociclib belongs to Oncology.
Why it happens
Additive hematologic toxicity affecting neutrophils.
What to do
Avoid if possible; if both are needed, monitor absolute neutrophil count more frequently and interrupt deferiprone for neutropenia or fever.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
- Deferiprone 500mg Film-coated Tablets - SmPC sections 4.3/4.5 (class statement: medicinal products known to be associated with neutropenia or those that can cause agranulocytosis; "patients must not take medicinal products known to be associated with neutropenia or those that can cause agranulocyto… — electronic medicines compendium (UK SmPC)
Other interactions of Deferiprone
- Clozapine + Deferiprone Contraindicated
- Abemaciclib + Deferiprone Major
- Acalabrutinib + Deferiprone Major
- Ado-trastuzumab emtansine + Deferiprone Major
- Ado-trastuzumab + Deferiprone Major
- Aldesleukin + Deferiprone Major
Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Frequently asked questions
Can I take Deferiprone with Ribociclib?
MediHelp rates the interaction as major. Deferiprone and Ribociclib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ribociclib commonly causes dose-related neutropenia, and deferiprone can cause agranulocytosis. Combined use may increase the risk of severe neutropenia and infection.
How serious is the interaction between Deferiprone and Ribociclib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; if both are needed, monitor absolute neutrophil count more frequently and interrupt deferiprone for neutropenia or fever.
What other medicines interact with Deferiprone?
MediHelp also lists interactions of Deferiprone with, for example, Clozapine, Abemaciclib, Acalabrutinib. The full list is on the Deferiprone page.
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