Drug interactions
Defibrotide + Escitalopram
Severity: Moderate
Defibrotide and Escitalopram: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Defibrotide has profibrinolytic and antithrombotic activity, and escitalopram impairs platelet function by depleting platelet serotonin. Used together they may increase the risk of bleeding.
What this interaction means in plain words
Defibrotide and Escitalopram can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Defibrotide belongs to Cardiovascular; Escitalopram belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic effects on hemostasis: SSRI-related platelet dysfunction plus defibrotide's profibrinolytic activity.
What to do
Monitor for signs of bleeding and check platelet count and coagulation parameters as clinically indicated. Hold defibrotide and reassess if significant bleeding occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Escitalopram
- Cisapride + Escitalopram Contraindicated
- Citalopram + Escitalopram Contraindicated
- Escitalopram + Isocarboxazid Contraindicated
- Escitalopram + Methylene blue Contraindicated
- Escitalopram + Phenelzine Contraindicated
- Escitalopram + Pimozide Contraindicated
Other interactions of Defibrotide
- Alteplase + Defibrotide Contraindicated
- Apixaban + Defibrotide Contraindicated
- Argatroban + Defibrotide Contraindicated
- Dabigatran etexilate + Defibrotide Contraindicated
- Dalteparin + Defibrotide Contraindicated
- Defibrotide + Edoxaban Contraindicated
Frequently asked questions
Can I take Defibrotide with Escitalopram?
MediHelp rates the interaction as moderate. Defibrotide and Escitalopram can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Defibrotide has profibrinolytic and antithrombotic activity, and escitalopram impairs platelet function by depleting platelet serotonin. Used together they may increase the risk of bleeding.
How serious is the interaction between Defibrotide and Escitalopram?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of bleeding and check platelet count and coagulation parameters as clinically indicated. Hold defibrotide and reassess if significant bleeding occurs.
What other medicines interact with Escitalopram?
MediHelp also lists interactions of Escitalopram with, for example, Cisapride, Citalopram, Isocarboxazid. The full list is on the Escitalopram page.
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