Drug interactions
Defibrotide + Fenoprofen
Severity: Moderate
Defibrotide and Fenoprofen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Defibrotide has profibrinolytic and antithrombotic activity, so combining it with NSAIDs that impair platelets may raise bleeding risk. Defibrotide labeling advises against concurrent use with anticoagulants or fibrinolytics, and caution applies to antiplatelet agents.
What this interaction means in plain words
Defibrotide and Fenoprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Defibrotide belongs to Cardiovascular; Fenoprofen belongs to Musculoskeletal.
Why it happens
Additive pharmacodynamic effects on hemostasis; a transporter-mediated effect is not established.
What to do
Monitor for bleeding signs and coagulation parameters, and avoid NSAIDs if an alternative analgesic is suitable.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fenoprofen
- Fenoprofen + Ketorolac Contraindicated
- Fenoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Fenoprofen Major
- Acemetacin + Fenoprofen Major
- Acetylsalicylic acid + Fenoprofen Major
- Alteplase + Fenoprofen Major
Other interactions of Defibrotide
- Alteplase + Defibrotide Contraindicated
- Apixaban + Defibrotide Contraindicated
- Argatroban + Defibrotide Contraindicated
- Dabigatran etexilate + Defibrotide Contraindicated
- Dalteparin + Defibrotide Contraindicated
- Defibrotide + Edoxaban Contraindicated
Frequently asked questions
Can I take Defibrotide with Fenoprofen?
MediHelp rates the interaction as moderate. Defibrotide and Fenoprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Defibrotide has profibrinolytic and antithrombotic activity, so combining it with NSAIDs that impair platelets may raise bleeding risk. Defibrotide labeling advises against concurrent use with anticoagulants or fibrinolytics, and caution applies to antiplatelet agents.
How serious is the interaction between Defibrotide and Fenoprofen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding signs and coagulation parameters, and avoid NSAIDs if an alternative analgesic is suitable.
What other medicines interact with Fenoprofen?
MediHelp also lists interactions of Fenoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Fenoprofen page.
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