Drug interactions
Deflazacort + Dronedarone
Severity: Moderate
Deflazacort and Dronedarone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dronedarone can raise exposure to the active metabolite of deflazacort, increasing corticosteroid adverse effects such as fluid retention, hyperglycemia and immunosuppression.
What this interaction means in plain words
Deflazacort and Dronedarone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deflazacort belongs to Miscellaneous; Dronedarone belongs to Cardiovascular.
Why it happens
Dronedarone inhibits CYP3A4 and P-glycoprotein, reducing clearance of deflazacort's active metabolite.
What to do
Reduce the deflazacort dose to one-third of the usual dose, as advised in its labeling for moderate CYP3A4 inhibitors, and monitor for corticosteroid adverse effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Other interactions of Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Contraindicated
- Bcg vaccine live + Deflazacort Contraindicated
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Deflazacort + Measles mumps and rubella vaccine Contraindicated
- Deflazacort + Measles mumps and rubella vaccine live Contraindicated
- Deflazacort + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Deflazacort with Dronedarone?
MediHelp rates the interaction as moderate. Deflazacort and Dronedarone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dronedarone can raise exposure to the active metabolite of deflazacort, increasing corticosteroid adverse effects such as fluid retention, hyperglycemia and immunosuppression.
How serious is the interaction between Deflazacort and Dronedarone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the deflazacort dose to one-third of the usual dose, as advised in its labeling for moderate CYP3A4 inhibitors, and monitor for corticosteroid adverse effects.
What other medicines interact with Dronedarone?
MediHelp also lists interactions of Dronedarone with, for example, Adagrasib, Amiodarone, Arsenic trioxide. The full list is on the Dronedarone page.
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