Drug interactions
Deflazacort + Ethacrynic acid
Severity: Moderate
Deflazacort and Ethacrynic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can lower serum potassium, so combined use may cause clinically significant hypokalemia. This can predispose to muscle weakness and cardiac arrhythmias, particularly in patients with heart disease or on digoxin.
What this interaction means in plain words
Deflazacort and Ethacrynic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deflazacort belongs to Miscellaneous; Ethacrynic acid belongs to Cardiovascular.
Why it happens
Loop diuretic-induced renal potassium wasting is added to the mineralocorticoid-related potassium loss caused by corticosteroids.
What to do
Monitor serum potassium and magnesium periodically, especially at the start of therapy or after dose changes. Give potassium supplementation as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Contraindicated
- Bcg vaccine live + Deflazacort Contraindicated
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Deflazacort + Measles mumps and rubella vaccine Contraindicated
- Deflazacort + Measles mumps and rubella vaccine live Contraindicated
- Deflazacort + Measles mumps rubella and varicella vaccine live Contraindicated
Other interactions of Ethacrynic acid
Frequently asked questions
Can I take Deflazacort with Ethacrynic acid?
MediHelp rates the interaction as moderate. Deflazacort and Ethacrynic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can lower serum potassium, so combined use may cause clinically significant hypokalemia. This can predispose to muscle weakness and cardiac arrhythmias, particularly in patients with heart disease or on digoxin.
How serious is the interaction between Deflazacort and Ethacrynic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and magnesium periodically, especially at the start of therapy or after dose changes. Give potassium supplementation as needed.
What other medicines interact with Deflazacort?
MediHelp also lists interactions of Deflazacort with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Deflazacort page.
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