Drug interactions
Deflazacort + Fluvoxamine
Severity: Moderate
Deflazacort and Fluvoxamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluvoxamine inhibits CYP3A4 to a modest degree, which can raise levels of the active metabolite of deflazacort. This may increase corticosteroid effects and adverse effects such as immunosuppression, fluid retention and hyperglycemia.
What this interaction means in plain words
Deflazacort and Fluvoxamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deflazacort belongs to Miscellaneous; Fluvoxamine belongs to Central Nervous System.
Why it happens
Fluvoxamine inhibits CYP3A4-mediated metabolism of deflazacort's active metabolite, increasing systemic exposure.
What to do
Watch for signs of excess corticosteroid effect and consider reducing the deflazacort dose, as labeling advises for moderate or strong CYP3A4 inhibitors. Reassess the dose if fluvoxamine is started or stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Other interactions of Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Contraindicated
- Bcg vaccine live + Deflazacort Contraindicated
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Deflazacort + Measles mumps and rubella vaccine Contraindicated
- Deflazacort + Measles mumps and rubella vaccine live Contraindicated
- Deflazacort + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Deflazacort with Fluvoxamine?
MediHelp rates the interaction as moderate. Deflazacort and Fluvoxamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluvoxamine inhibits CYP3A4 to a modest degree, which can raise levels of the active metabolite of deflazacort. This may increase corticosteroid effects and adverse effects such as immunosuppression, fluid retention and hyperglycemia.
How serious is the interaction between Deflazacort and Fluvoxamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Watch for signs of excess corticosteroid effect and consider reducing the deflazacort dose, as labeling advises for moderate or strong CYP3A4 inhibitors. Reassess the dose if fluvoxamine is started or stopped.
What other medicines interact with Fluvoxamine?
MediHelp also lists interactions of Fluvoxamine with, for example, Agomelatine, Alosetron, Fezolinetant. The full list is on the Fluvoxamine page.
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