Drug interactions
Deflazacort + Fondaparinux
Severity: Minor
Deflazacort and Fondaparinux: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic corticosteroids can raise GI bleeding risk through mucosal injury and may impair vascular integrity. The INR-related warning applies to warfarin, not fondaparinux, so the effect here is bleeding risk rather than altered anticoagulant potency.
What this interaction means in plain words
Deflazacort and Fondaparinux have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Deflazacort belongs to Miscellaneous; Fondaparinux belongs to Cardiovascular.
Why it happens
Corticosteroid-related mucosal injury and vascular fragility add to the bleeding risk of anticoagulation; no pharmacokinetic interaction.
What to do
Watch for signs of GI bleeding, especially with prolonged or high-dose steroid use. Add gastroprotection if other risk factors are present.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fondaparinux
- Defibrotide + Fondaparinux Contraindicated
- Fondaparinux + Ketorolac Contraindicated
- Abciximab + Fondaparinux Major
- Aceclofenac + Fondaparinux Major
- Acetylsalicylic acid + Fondaparinux Major
- Alteplase + Fondaparinux Major
Other interactions of Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Contraindicated
- Bcg vaccine live + Deflazacort Contraindicated
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Deflazacort + Measles mumps and rubella vaccine Contraindicated
- Deflazacort + Measles mumps and rubella vaccine live Contraindicated
- Deflazacort + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Deflazacort with Fondaparinux?
MediHelp rates the interaction as minor. Deflazacort and Fondaparinux have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Systemic corticosteroids can raise GI bleeding risk through mucosal injury and may impair vascular integrity. The INR-related warning applies to warfarin, not fondaparinux, so the effect here is bleeding risk rather than altered anticoagulant potency.
How serious is the interaction between Deflazacort and Fondaparinux?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Watch for signs of GI bleeding, especially with prolonged or high-dose steroid use. Add gastroprotection if other risk factors are present.
What other medicines interact with Fondaparinux?
MediHelp also lists interactions of Fondaparinux with, for example, Defibrotide, Ketorolac, Abciximab. The full list is on the Fondaparinux page.
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