Drug interactions
Deflazacort + Furosemide
Severity: Moderate
Deflazacort and Furosemide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids such as deflazacort promote potassium excretion, and combined with furosemide this can cause significant hypokalemia, with a risk of arrhythmias and muscle weakness. Fluid retention from the steroid may also reduce diuretic effectiveness.
What this interaction means in plain words
Deflazacort and Furosemide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deflazacort belongs to Miscellaneous; Furosemide belongs to Cardiovascular.
Why it happens
Additive renal potassium wasting through loop diuretic action and glucocorticoid mineralocorticoid activity.
What to do
Monitor serum potassium and magnesium regularly and supplement as needed. Watch for fluid retention and adjust the diuretic dose accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Furosemide
- Amifostine + Furosemide Major
- Amikacin + Furosemide Major
- Carbenoxolone + Furosemide Major
- Cephaloridine + Furosemide Major
- Cisplatin + Furosemide Major
- Digoxin + Furosemide Major
Other interactions of Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Contraindicated
- Bcg vaccine live + Deflazacort Contraindicated
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Deflazacort + Measles mumps and rubella vaccine Contraindicated
- Deflazacort + Measles mumps and rubella vaccine live Contraindicated
- Deflazacort + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Deflazacort with Furosemide?
MediHelp rates the interaction as moderate. Deflazacort and Furosemide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticosteroids such as deflazacort promote potassium excretion, and combined with furosemide this can cause significant hypokalemia, with a risk of arrhythmias and muscle weakness. Fluid retention from the steroid may also reduce diuretic effectiveness.
How serious is the interaction between Deflazacort and Furosemide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and magnesium regularly and supplement as needed. Watch for fluid retention and adjust the diuretic dose accordingly.
What other medicines interact with Furosemide?
MediHelp also lists interactions of Furosemide with, for example, Amifostine, Amikacin, Carbenoxolone. The full list is on the Furosemide page.
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