Drug interactions
Deflazacort + Gentamicin
Severity: Moderate
Deflazacort and Gentamicin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids such as deflazacort promote urinary potassium loss, and gentamicin can cause renal potassium and magnesium wasting. Combined use may increase the risk of hypokalemia and hypomagnesemia, which matters for patients with arrhythmia risk or muscle weakness.
What this interaction means in plain words
Deflazacort and Gentamicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deflazacort belongs to Miscellaneous; Gentamicin belongs to Anti Bacterial.
Why it happens
Additive renal electrolyte wasting from mineralocorticoid effect of the steroid and aminoglycoside tubular toxicity.
What to do
Monitor serum potassium and magnesium, and replace as needed during prolonged combined therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gentamicin
- Cidofovir + Gentamicin Contraindicated
- Adefovir + Gentamicin Major
- Amikacin + Gentamicin Major
- Amlodipine-hydrochlorothiazide-valsartan + Gentamicin Major
- Amphotericin b deoxycholate + Gentamicin Major
- Amphotericin b + Gentamicin Major
Other interactions of Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Contraindicated
- Bcg vaccine live + Deflazacort Contraindicated
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Deflazacort + Measles mumps and rubella vaccine Contraindicated
- Deflazacort + Measles mumps and rubella vaccine live Contraindicated
- Deflazacort + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Deflazacort with Gentamicin?
MediHelp rates the interaction as moderate. Deflazacort and Gentamicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticosteroids such as deflazacort promote urinary potassium loss, and gentamicin can cause renal potassium and magnesium wasting. Combined use may increase the risk of hypokalemia and hypomagnesemia, which matters for patients with arrhythmia risk or muscle weakness.
How serious is the interaction between Deflazacort and Gentamicin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and magnesium, and replace as needed during prolonged combined therapy.
What other medicines interact with Gentamicin?
MediHelp also lists interactions of Gentamicin with, for example, Cidofovir, Adefovir, Amikacin. The full list is on the Gentamicin page.
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