Drug interactions
Deflazacort + Haloperidol
Severity: Minor
Deflazacort and Haloperidol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Haloperidol is a weak to moderate CYP3A4 inhibitor and may increase exposure to deflazacort's active metabolite. This may increase corticosteroid adverse effects.
What this interaction means in plain words
Deflazacort and Haloperidol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Deflazacort belongs to Miscellaneous; Haloperidol belongs to Central Nervous System.
Why it happens
Haloperidol inhibition of CYP3A4-mediated clearance of deflazacort's active metabolite.
What to do
Monitor for corticosteroid adverse effects such as fluid retention and hyperglycemia. Consider reducing the deflazacort dose if effects appear.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Other interactions of Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Contraindicated
- Bcg vaccine live + Deflazacort Contraindicated
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Deflazacort + Measles mumps and rubella vaccine Contraindicated
- Deflazacort + Measles mumps and rubella vaccine live Contraindicated
- Deflazacort + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Deflazacort with Haloperidol?
MediHelp rates the interaction as minor. Deflazacort and Haloperidol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Haloperidol is a weak to moderate CYP3A4 inhibitor and may increase exposure to deflazacort's active metabolite. This may increase corticosteroid adverse effects.
How serious is the interaction between Deflazacort and Haloperidol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for corticosteroid adverse effects such as fluid retention and hyperglycemia. Consider reducing the deflazacort dose if effects appear.
What other medicines interact with Haloperidol?
MediHelp also lists interactions of Haloperidol with, for example, Dofetilide, Dronedarone, Ibutilide. The full list is on the Haloperidol page.
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