Drug interactions
Deflazacort + Lornoxicam
Severity: Moderate
Deflazacort and Lornoxicam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids combined with NSAIDs increase the risk of gastric irritation, ulceration and gastrointestinal bleeding. The risk is higher in older patients and those with prior ulcer disease.
What this interaction means in plain words
Deflazacort and Lornoxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deflazacort belongs to Miscellaneous; Lornoxicam belongs to Musculoskeletal.
Why it happens
Additive gastrointestinal mucosal injury: NSAID prostaglandin inhibition plus corticosteroid impairment of mucosal protection and healing.
What to do
Use the lowest effective doses for the shortest time and consider a proton pump inhibitor for gastroprotection; counsel patients to report black stools or abdominal pain.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Contraindicated
- Bcg vaccine live + Deflazacort Contraindicated
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Deflazacort + Measles mumps and rubella vaccine Contraindicated
- Deflazacort + Measles mumps and rubella vaccine live Contraindicated
- Deflazacort + Measles mumps rubella and varicella vaccine live Contraindicated
Other interactions of Lornoxicam
Frequently asked questions
Can I take Deflazacort with Lornoxicam?
MediHelp rates the interaction as moderate. Deflazacort and Lornoxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticosteroids combined with NSAIDs increase the risk of gastric irritation, ulceration and gastrointestinal bleeding. The risk is higher in older patients and those with prior ulcer disease.
How serious is the interaction between Deflazacort and Lornoxicam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses for the shortest time and consider a proton pump inhibitor for gastroprotection; counsel patients to report black stools or abdominal pain.
What other medicines interact with Deflazacort?
MediHelp also lists interactions of Deflazacort with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Deflazacort page.
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