Drug interactions
Deflazacort + Ribociclib
Severity: Major
Deflazacort and Ribociclib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ribociclib is a strong CYP3A4 inhibitor and can raise exposure to deflazacort's active metabolite. This may increase corticosteroid adverse effects such as infection, hyperglycemia and adrenal suppression.
What this interaction means in plain words
Deflazacort and Ribociclib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Deflazacort belongs to Miscellaneous; Ribociclib belongs to Oncology.
Why it happens
CYP3A4 inhibition by ribociclib reduces the clearance of deflazacort's active metabolite 21-desDFZ.
What to do
Avoid if possible; otherwise follow the labeled reduction of deflazacort to about two-thirds of the usual dose and monitor for corticosteroid toxicity.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Other interactions of Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Contraindicated
- Bcg vaccine live + Deflazacort Contraindicated
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Deflazacort + Measles mumps and rubella vaccine Contraindicated
- Deflazacort + Measles mumps and rubella vaccine live Contraindicated
- Deflazacort + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Deflazacort with Ribociclib?
MediHelp rates the interaction as major. Deflazacort and Ribociclib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ribociclib is a strong CYP3A4 inhibitor and can raise exposure to deflazacort's active metabolite. This may increase corticosteroid adverse effects such as infection, hyperglycemia and adrenal suppression.
How serious is the interaction between Deflazacort and Ribociclib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; otherwise follow the labeled reduction of deflazacort to about two-thirds of the usual dose and monitor for corticosteroid toxicity.
What other medicines interact with Ribociclib?
MediHelp also lists interactions of Ribociclib with, for example, Amiodarone, Cisapride, Dofetilide. The full list is on the Ribociclib page.
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