Drug interactions
Deflazacort + Rosiglitazone
Severity: Minor
Deflazacort and Rosiglitazone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Deflazacort is a glucocorticoid that raises blood glucose and can reduce the glucose-lowering effect of rosiglitazone. Loss of glycemic control may occur, particularly with prolonged or high-dose corticosteroid use.
What this interaction means in plain words
Deflazacort and Rosiglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Deflazacort belongs to Miscellaneous; Rosiglitazone belongs to Endocrine.
Why it happens
Glucocorticoids promote hepatic gluconeogenesis and insulin resistance, opposing the insulin-sensitizing action of rosiglitazone.
What to do
Monitor blood glucose and HbA1c during deflazacort therapy and adjust the antidiabetic regimen if control worsens. Reassess doses when the corticosteroid is tapered or stopped.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Rosiglitazone
- Insulin aspart protamine / insulin aspart + Rosiglitazone Major
- Insulin aspart-insulin aspart protamine + Rosiglitazone Major
- Insulin aspart + Rosiglitazone Major
- Insulin degludec / insulin aspart + Rosiglitazone Major
- Insulin degludec-insulin aspart + Rosiglitazone Major
- Insulin degludec-liraglutide + Rosiglitazone Major
Other interactions of Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Contraindicated
- Bcg vaccine live + Deflazacort Contraindicated
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Deflazacort + Measles mumps and rubella vaccine Contraindicated
- Deflazacort + Measles mumps and rubella vaccine live Contraindicated
- Deflazacort + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Deflazacort with Rosiglitazone?
MediHelp rates the interaction as minor. Deflazacort and Rosiglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Deflazacort is a glucocorticoid that raises blood glucose and can reduce the glucose-lowering effect of rosiglitazone. Loss of glycemic control may occur, particularly with prolonged or high-dose corticosteroid use.
How serious is the interaction between Deflazacort and Rosiglitazone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c during deflazacort therapy and adjust the antidiabetic regimen if control worsens. Reassess doses when the corticosteroid is tapered or stopped.
What other medicines interact with Rosiglitazone?
MediHelp also lists interactions of Rosiglitazone with, for example, Insulin aspart protamine / insulin aspart, Insulin aspart-insulin aspart protamine, Insulin aspart. The full list is on the Rosiglitazone page.
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