Drug interactions
Degarelix + Desflurane
Severity: Moderate
Degarelix and Desflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Degarelix, like other androgen deprivation therapies, can prolong the QT interval, and desflurane may add to this. The additive effect is probably modest but may matter in patients with other risk factors.
What this interaction means in plain words
Degarelix and Desflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Degarelix belongs to Endocrine; Desflurane belongs to Central Nervous System.
Why it happens
Additive QT prolongation, with androgen deprivation affecting cardiac repolarization.
What to do
Review baseline ECG and electrolytes in patients with other QT risk factors. Monitor the ECG during anesthesia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desflurane
Other interactions of Degarelix
- Degarelix + Pimozide Contraindicated
- Degarelix + Thioridazine Contraindicated
- Amiodarone + Degarelix Major
- Amisulpride + Degarelix Major
- Anagrelide + Degarelix Major
- Cisapride + Degarelix Major
Frequently asked questions
Can I take Degarelix with Desflurane?
MediHelp rates the interaction as moderate. Degarelix and Desflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Degarelix, like other androgen deprivation therapies, can prolong the QT interval, and desflurane may add to this. The additive effect is probably modest but may matter in patients with other risk factors.
How serious is the interaction between Degarelix and Desflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Review baseline ECG and electrolytes in patients with other QT risk factors. Monitor the ECG during anesthesia.
What other medicines interact with Desflurane?
MediHelp also lists interactions of Desflurane with, for example, Amisulpride, Anagrelide, Arsenic trioxide. The full list is on the Desflurane page.
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