Drug interactions
Degarelix + Fluconazole
Severity: Moderate
Degarelix and Fluconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Degarelix, like other androgen deprivation therapies, may prolong the QT interval, and fluconazole also has this effect. Combined use may add to the risk of QT prolongation and torsades de pointes, especially with other risk factors.
What this interaction means in plain words
Degarelix and Fluconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Degarelix belongs to Endocrine; Fluconazole belongs to Anti Fungals.
Why it happens
Additive prolongation of cardiac repolarization.
What to do
Check baseline ECG and electrolytes and correct potassium and magnesium. Monitor ECG during concurrent therapy in patients with cardiac risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
- Flibanserin + Fluconazole Contraindicated
Other interactions of Degarelix
- Degarelix + Pimozide Contraindicated
- Degarelix + Thioridazine Contraindicated
- Amiodarone + Degarelix Major
- Amisulpride + Degarelix Major
- Anagrelide + Degarelix Major
- Cisapride + Degarelix Major
Frequently asked questions
Can I take Degarelix with Fluconazole?
MediHelp rates the interaction as moderate. Degarelix and Fluconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Degarelix, like other androgen deprivation therapies, may prolong the QT interval, and fluconazole also has this effect. Combined use may add to the risk of QT prolongation and torsades de pointes, especially with other risk factors.
How serious is the interaction between Degarelix and Fluconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline ECG and electrolytes and correct potassium and magnesium. Monitor ECG during concurrent therapy in patients with cardiac risk factors.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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