Drug interactions
Degarelix + Itraconazole
Severity: Moderate
Degarelix and Itraconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Androgen deprivation therapy with degarelix and itraconazole can each prolong the QT interval. Combined use may raise the risk of torsades de pointes, particularly with other risk factors.
What this interaction means in plain words
Degarelix and Itraconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Degarelix belongs to Endocrine; Itraconazole belongs to Anti Fungals.
Why it happens
Additive QT prolongation.
What to do
Obtain a baseline ECG and correct electrolyte abnormalities. Monitor the QTc during co-administration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Degarelix and Itraconazole, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Other interactions of Degarelix
- Degarelix + Pimozide Contraindicated
- Degarelix + Thioridazine Contraindicated
- Amiodarone + Degarelix Major
- Amisulpride + Degarelix Major
- Anagrelide + Degarelix Major
- Cisapride + Degarelix Major
Frequently asked questions
Can I take Degarelix with Itraconazole?
MediHelp rates the interaction as moderate. Degarelix and Itraconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Androgen deprivation therapy with degarelix and itraconazole can each prolong the QT interval. Combined use may raise the risk of torsades de pointes, particularly with other risk factors.
How serious is the interaction between Degarelix and Itraconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct electrolyte abnormalities. Monitor the QTc during co-administration.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
