Drug interactions
Degarelix + Mefloquine
Severity: Moderate
Degarelix and Mefloquine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Degarelix, like other androgen deprivation therapy, may prolong the QT interval, and mefloquine has similar effects. Together they may increase the risk of serious ventricular arrhythmia, especially in older patients with cardiac disease.
What this interaction means in plain words
Degarelix and Mefloquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Degarelix belongs to Endocrine; Mefloquine belongs to Anti Parasitic.
Why it happens
Additive QT prolongation; androgen deprivation alters cardiac repolarization while mefloquine affects cardiac ion channels.
What to do
Check a baseline ECG and electrolytes, and monitor the QTc during co-administration. Prefer a non-QT-prolonging antimalarial where one is suitable.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mefloquine
- Arsenic trioxide + Mefloquine Contraindicated
- Dronedarone + Mefloquine Contraindicated
- Ibutilide + Mefloquine Contraindicated
- Levoketoconazole + Mefloquine Contraindicated
- Mefloquine + Nilotinib Contraindicated
- Mefloquine + Pimozide Contraindicated
Other interactions of Degarelix
- Degarelix + Pimozide Contraindicated
- Degarelix + Thioridazine Contraindicated
- Amiodarone + Degarelix Major
- Amisulpride + Degarelix Major
- Anagrelide + Degarelix Major
- Cisapride + Degarelix Major
Frequently asked questions
Can I take Degarelix with Mefloquine?
MediHelp rates the interaction as moderate. Degarelix and Mefloquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Degarelix, like other androgen deprivation therapy, may prolong the QT interval, and mefloquine has similar effects. Together they may increase the risk of serious ventricular arrhythmia, especially in older patients with cardiac disease.
How serious is the interaction between Degarelix and Mefloquine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check a baseline ECG and electrolytes, and monitor the QTc during co-administration. Prefer a non-QT-prolonging antimalarial where one is suitable.
What other medicines interact with Mefloquine?
MediHelp also lists interactions of Mefloquine with, for example, Arsenic trioxide, Dronedarone, Ibutilide. The full list is on the Mefloquine page.
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