Drug interactions
Degarelix + Promethazine
Severity: Major
Degarelix and Promethazine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The concurrent use of promethazine and degarelix may lead to a significant reduction in the QTc interval, which could potentially result in adverse cardiac effects. Patients taking both medications should be closely monitored for any signs of arrhythmias or other cardiac complications.
What this interaction means in plain words
Degarelix and Promethazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Degarelix belongs to Endocrine; Promethazine belongs to Respiratory.
Why it happens
Both drugs have properties that can influence cardiac repolarization, leading to changes in the QT interval. However, the exact mechanism of interaction between these two agents is not fully understood.
What to do
It is advisable to avoid the combination of these two medications whenever possible. If their concurrent use is necessary, patients should be monitored for cardiac symptoms and QTc interval changes.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Promethazine
- Cabergoline + Promethazine Contraindicated
- Dopamine + Promethazine Contraindicated
- Ibutilide + Promethazine Contraindicated
- Pimozide + Promethazine Contraindicated
- Promethazine + Thioridazine Contraindicated
- Alfentanil + Promethazine Major
Other interactions of Degarelix
- Degarelix + Pimozide Contraindicated
- Degarelix + Thioridazine Contraindicated
- Amiodarone + Degarelix Major
- Amisulpride + Degarelix Major
- Anagrelide + Degarelix Major
- Cisapride + Degarelix Major
Frequently asked questions
Can I take Degarelix with Promethazine?
MediHelp rates the interaction as major. Degarelix and Promethazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. The concurrent use of promethazine and degarelix may lead to a significant reduction in the QTc interval, which could potentially result in adverse cardiac effects. Patients taking both medications should be closely monitored for any signs of arrhythmias or other cardiac complications.
How serious is the interaction between Degarelix and Promethazine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: It is advisable to avoid the combination of these two medications whenever possible. If their concurrent use is necessary, patients should be monitored for cardiac symptoms and QTc interval changes.
What other medicines interact with Promethazine?
MediHelp also lists interactions of Promethazine with, for example, Cabergoline, Dopamine, Ibutilide. The full list is on the Promethazine page.
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