Drug interactions
Degarelix + Ribociclib
Severity: Major
Degarelix and Ribociclib: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both ribociclib and degarelix can prolong the QT interval. Combined use increases the risk of serious ventricular arrhythmias such as torsades de pointes.
What this interaction means in plain words
Degarelix and Ribociclib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Degarelix belongs to Endocrine; Ribociclib belongs to Oncology.
Why it happens
Additive QTc prolongation through pharmacodynamic synergy.
What to do
Avoid the combination where possible. If used, monitor ECG and electrolytes at baseline and during treatment and interrupt or reduce ribociclib if QTc becomes prolonged.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Other interactions of Degarelix
- Degarelix + Pimozide Contraindicated
- Degarelix + Thioridazine Contraindicated
- Amiodarone + Degarelix Major
- Amisulpride + Degarelix Major
- Anagrelide + Degarelix Major
- Cisapride + Degarelix Major
Frequently asked questions
Can I take Degarelix with Ribociclib?
MediHelp rates the interaction as major. Degarelix and Ribociclib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both ribociclib and degarelix can prolong the QT interval. Combined use increases the risk of serious ventricular arrhythmias such as torsades de pointes.
How serious is the interaction between Degarelix and Ribociclib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible. If used, monitor ECG and electrolytes at baseline and during treatment and interrupt or reduce ribociclib if QTc becomes prolonged.
What other medicines interact with Ribociclib?
MediHelp also lists interactions of Ribociclib with, for example, Amiodarone, Cisapride, Dofetilide. The full list is on the Ribociclib page.
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