Drug interactions
Delafloxacin + Didanosine
Severity: Moderate
Delafloxacin and Didanosine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Buffered didanosine formulations contain aluminum and magnesium that bind delafloxacin and reduce its absorption, risking treatment failure.
What this interaction means in plain words
Delafloxacin and Didanosine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Delafloxacin belongs to Anti Bacterial; Didanosine belongs to Anti Virals.
Why it happens
Chelation of delafloxacin by the polyvalent cations in buffered didanosine reduces absorption.
What to do
Take delafloxacin at least 2 hours before or 6 hours after buffered didanosine. Use intravenous delafloxacin if separation is impractical.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Delafloxacin
- Aluminum hydroxide + Delafloxacin Moderate
- Calcium carbonate + Delafloxacin Moderate
- Calcium + Delafloxacin Moderate
- Carbonyl iron + Delafloxacin Moderate
- Delafloxacin + Ferrous fumarate Moderate
- Delafloxacin + Ferrous gluconate Moderate
Other interactions of Didanosine
- Didanosine + Elvitegravir / cobicistat / emtricitabine / tenofovir df Contraindicated
- Didanosine + Hydroxycarbamide Contraindicated
- Didanosine + Hydroxyurea Contraindicated
- Didanosine + Ribavirin Contraindicated
- Didanosine + Stavudine Contraindicated
- Allopurinol + Didanosine Major
Frequently asked questions
Can I take Delafloxacin with Didanosine?
MediHelp rates the interaction as moderate. Delafloxacin and Didanosine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Buffered didanosine formulations contain aluminum and magnesium that bind delafloxacin and reduce its absorption, risking treatment failure.
How serious is the interaction between Delafloxacin and Didanosine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Take delafloxacin at least 2 hours before or 6 hours after buffered didanosine. Use intravenous delafloxacin if separation is impractical.
What other medicines interact with Delafloxacin?
MediHelp also lists interactions of Delafloxacin with, for example, Aluminum hydroxide, Calcium carbonate, Calcium. The full list is on the Delafloxacin page.
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