Drug interactions
Calcium + Delafloxacin
Severity: Moderate
Calcium and Delafloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Calcium salts can bind oral delafloxacin in the gut, reducing its absorption and potentially causing treatment failure. The effect is well described for fluoroquinolones with polyvalent cations.
What this interaction means in plain words
Calcium and Delafloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Calcium belongs to Gastrointestinal Tract; Delafloxacin belongs to Anti Bacterial.
Why it happens
Chelation of delafloxacin by calcium cations in the gastrointestinal tract, reducing absorption.
What to do
Give oral delafloxacin at least 2 hours before or 6 hours after calcium products.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Calcium
- Calcium + Ceftriaxone Contraindicated
- Acalabrutinib + Calcium Moderate
- Alendronate + Calcium Moderate
- Atazanavir + Calcium Moderate
- Baloxavir marboxil + Calcium Moderate
- Bendroflumethiazide + Calcium Moderate
Other interactions of Delafloxacin
- Aluminum hydroxide + Delafloxacin Moderate
- Calcium carbonate + Delafloxacin Moderate
- Carbonyl iron + Delafloxacin Moderate
- Delafloxacin + Didanosine Moderate
- Delafloxacin + Ferrous fumarate Moderate
- Delafloxacin + Ferrous gluconate Moderate
Frequently asked questions
Can I take Calcium with Delafloxacin?
MediHelp rates the interaction as moderate. Calcium and Delafloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Calcium salts can bind oral delafloxacin in the gut, reducing its absorption and potentially causing treatment failure. The effect is well described for fluoroquinolones with polyvalent cations.
How serious is the interaction between Calcium and Delafloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give oral delafloxacin at least 2 hours before or 6 hours after calcium products.
What other medicines interact with Calcium?
MediHelp also lists interactions of Calcium with, for example, Ceftriaxone, Acalabrutinib, Alendronate. The full list is on the Calcium page.
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