Drug interactions
Dengue vaccine + Everolimus
Severity: Major
Dengue vaccine and Everolimus: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dengue vaccine is a live attenuated vaccine, and immunosuppression from everolimus may both blunt the response and permit uncontrolled vaccine virus replication. Vaccination is generally not advised in significantly immunosuppressed patients.
What this interaction means in plain words
Dengue vaccine and Everolimus can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
mTOR inhibition suppresses lymphocyte function, reducing vaccine immunogenicity and impairing control of a live virus.
What to do
Avoid live dengue vaccine in patients on everolimus, particularly transplant recipients. If vaccination is needed, defer until immunosuppression is stopped or reduced per specialist advice.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Everolimus
- Bcg vaccine live + Everolimus Contraindicated
- Everolimus + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Everolimus + Levoketoconazole Contraindicated
- Everolimus + Measles mumps and rubella vaccine live Contraindicated
- Everolimus + Measles mumps rubella and varicella vaccine live Contraindicated
- Everolimus + Measles vaccine Contraindicated
Frequently asked questions
Can I take Dengue vaccine with Everolimus?
MediHelp rates the interaction as major. Dengue vaccine and Everolimus can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dengue vaccine is a live attenuated vaccine, and immunosuppression from everolimus may both blunt the response and permit uncontrolled vaccine virus replication. Vaccination is generally not advised in significantly immunosuppressed patients.
How serious is the interaction between Dengue vaccine and Everolimus?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid live dengue vaccine in patients on everolimus, particularly transplant recipients. If vaccination is needed, defer until immunosuppression is stopped or reduced per specialist advice.
What other medicines interact with Everolimus?
MediHelp also lists interactions of Everolimus with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Levoketoconazole. The full list is on the Everolimus page.
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