Drug interactions
Dengue vaccine + Golimumab
Severity: Major
Dengue vaccine and Golimumab: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dengue vaccine (Dengvaxia) is a live attenuated vaccine, and golimumab-induced immunosuppression raises the concern of vaccine-strain infection and a poorer response. Live vaccines are generally avoided in patients on TNF inhibitors.
What this interaction means in plain words
Dengue vaccine and Golimumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
TNF blockade impairs control of live attenuated virus replication and reduces vaccine immune response.
What to do
Avoid live dengue vaccine during golimumab therapy; vaccinate before starting treatment where possible. Follow labeled intervals before starting or after stopping golimumab.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Golimumab
- Bcg vaccine live + Golimumab Contraindicated
- Etanercept + Golimumab Contraindicated
- Golimumab + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Golimumab + Measles mumps and rubella vaccine Contraindicated
- Golimumab + Measles mumps and rubella vaccine live Contraindicated
- Golimumab + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Dengue vaccine with Golimumab?
MediHelp rates the interaction as major. Dengue vaccine and Golimumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dengue vaccine (Dengvaxia) is a live attenuated vaccine, and golimumab-induced immunosuppression raises the concern of vaccine-strain infection and a poorer response. Live vaccines are generally avoided in patients on TNF inhibitors.
How serious is the interaction between Dengue vaccine and Golimumab?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid live dengue vaccine during golimumab therapy; vaccinate before starting treatment where possible. Follow labeled intervals before starting or after stopping golimumab.
What other medicines interact with Golimumab?
MediHelp also lists interactions of Golimumab with, for example, Bcg vaccine live, Etanercept, Influenza virus vaccine quadrivalent intranasal. The full list is on the Golimumab page.
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