Drug interactions
Dengue vaccine + Hydroxychloroquine
Severity: Minor
Dengue vaccine and Hydroxychloroquine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The dengue vaccine is live attenuated. Hydroxychloroquine is only weakly immunomodulatory and is not generally regarded as significantly immunosuppressive, so the interaction is of limited clinical importance. Chloroquine-type drugs have been shown to affect responses to some live vaccines.
What this interaction means in plain words
Dengue vaccine and Hydroxychloroquine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Mild immunomodulation may slightly alter the immune response to a live vaccine.
What to do
Vaccination is generally acceptable. Confirm eligibility according to the vaccine label and the patient's overall immune status.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydroxychloroquine
- Arsenic trioxide + Hydroxychloroquine Contraindicated
- Cisapride + Hydroxychloroquine Contraindicated
- Dronedarone + Hydroxychloroquine Contraindicated
- Hydroxychloroquine + Pimozide Contraindicated
- Hydroxychloroquine + Thioridazine Contraindicated
- Hydroxychloroquine + Vandetanib Contraindicated
Frequently asked questions
Can I take Dengue vaccine with Hydroxychloroquine?
MediHelp rates the interaction as minor. Dengue vaccine and Hydroxychloroquine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. The dengue vaccine is live attenuated. Hydroxychloroquine is only weakly immunomodulatory and is not generally regarded as significantly immunosuppressive, so the interaction is of limited clinical importance. Chloroquine-type drugs have been shown to affect responses to some live vaccines.
How serious is the interaction between Dengue vaccine and Hydroxychloroquine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccination is generally acceptable. Confirm eligibility according to the vaccine label and the patient's overall immune status.
What other medicines interact with Hydroxychloroquine?
MediHelp also lists interactions of Hydroxychloroquine with, for example, Arsenic trioxide, Cisapride, Dronedarone. The full list is on the Hydroxychloroquine page.
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