Drug interactions
Dengue vaccine + Infliximab
Severity: Major
Dengue vaccine and Infliximab: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dengue vaccine is a live attenuated vaccine, and infliximab impairs immune responses. Vaccination may be less effective and live vaccine replication could cause disease in immunosuppressed patients.
What this interaction means in plain words
Dengue vaccine and Infliximab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
TNF blockade-induced immunosuppression reduces vaccine response and permits uncontrolled replication of live vaccine virus.
What to do
Avoid live dengue vaccine during infliximab therapy and for several months after stopping. Use mosquito-avoidance measures instead.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Infliximab
- Bcg vaccine live + Infliximab Contraindicated
- Infliximab + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Infliximab + Measles mumps and rubella vaccine Contraindicated
- Infliximab + Measles mumps and rubella vaccine live Contraindicated
- Infliximab + Measles mumps rubella and varicella vaccine live Contraindicated
- Infliximab + Measles vaccine Contraindicated
Frequently asked questions
Can I take Dengue vaccine with Infliximab?
MediHelp rates the interaction as major. Dengue vaccine and Infliximab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dengue vaccine is a live attenuated vaccine, and infliximab impairs immune responses. Vaccination may be less effective and live vaccine replication could cause disease in immunosuppressed patients.
How serious is the interaction between Dengue vaccine and Infliximab?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid live dengue vaccine during infliximab therapy and for several months after stopping. Use mosquito-avoidance measures instead.
What other medicines interact with Infliximab?
MediHelp also lists interactions of Infliximab with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine. The full list is on the Infliximab page.
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