Drug interactions
Dengue vaccine + Methylprednisolone
Severity: Major
Dengue vaccine and Methylprednisolone: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids at greater than physiologic doses can blunt the immune response to the live attenuated dengue vaccine and may increase the risk of vaccine-related infection. Protection from the vaccine may therefore be inadequate.
What this interaction means in plain words
Dengue vaccine and Methylprednisolone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Corticosteroid-induced immunosuppression reduces the vaccine response and permits uncontrolled replication of the live vaccine virus.
What to do
Avoid giving the live vaccine during immunosuppressive steroid therapy and defer vaccination until the steroid has been stopped for the interval stated in the product labeling or local guidance.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Methylprednisolone
- Bcg vaccine live + Methylprednisolone Contraindicated
- Measles mumps and rubella vaccine live + Methylprednisolone Contraindicated
- Measles mumps rubella and varicella vaccine live + Methylprednisolone Contraindicated
- Measles vaccine + Methylprednisolone Contraindicated
- Methylprednisolone + Mifepristone Contraindicated
- Methylprednisolone + Rubella vaccine Contraindicated
Frequently asked questions
Can I take Dengue vaccine with Methylprednisolone?
MediHelp rates the interaction as major. Dengue vaccine and Methylprednisolone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Corticosteroids at greater than physiologic doses can blunt the immune response to the live attenuated dengue vaccine and may increase the risk of vaccine-related infection. Protection from the vaccine may therefore be inadequate.
How serious is the interaction between Dengue vaccine and Methylprednisolone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid giving the live vaccine during immunosuppressive steroid therapy and defer vaccination until the steroid has been stopped for the interval stated in the product labeling or local guidance.
What other medicines interact with Methylprednisolone?
MediHelp also lists interactions of Methylprednisolone with, for example, Bcg vaccine live, Measles mumps and rubella vaccine live, Measles mumps rubella and varicella vaccine live. The full list is on the Methylprednisolone page.
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