Drug interactions
Dengue vaccine + Temozolomide
Severity: Major
Dengue vaccine and Temozolomide: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The dengue vaccine is a live attenuated vaccine. In patients on temozolomide, immune response may be reduced and live virus replication may be less controlled.
What this interaction means in plain words
Dengue vaccine and Temozolomide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Chemotherapy-induced immunosuppression reduces vaccine response and may permit uncontrolled replication of live attenuated virus.
What to do
Avoid live vaccination during chemotherapy and defer until immune recovery per vaccine labeling and local guidance.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Temozolomide
Frequently asked questions
Can I take Dengue vaccine with Temozolomide?
MediHelp rates the interaction as major. Dengue vaccine and Temozolomide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. The dengue vaccine is a live attenuated vaccine. In patients on temozolomide, immune response may be reduced and live virus replication may be less controlled.
How serious is the interaction between Dengue vaccine and Temozolomide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid live vaccination during chemotherapy and defer until immune recovery per vaccine labeling and local guidance.
What other medicines interact with Temozolomide?
MediHelp also lists interactions of Temozolomide with, for example, Adenovirus types 4 and 7 live, Belatacept, Deferiprone. The full list is on the Temozolomide page.
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