Drug interactions
Fingolimod + Temozolomide
Severity: Major
Fingolimod and Temozolomide: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Temozolomide causes myelosuppression and lymphopenia, which add to fingolimod's lowering of lymphocytes. This may increase risk of infection, including opportunistic infections.
What this interaction means in plain words
Fingolimod and Temozolomide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fingolimod belongs to Central Nervous System; Temozolomide belongs to Oncology.
Why it happens
Additive lymphopenia from alkylating-agent marrow suppression and fingolimod lymphocyte sequestration.
What to do
Avoid if possible; if used, monitor lymphocyte and neutrophil counts and consider infection prophylaxis per local practice. Consider suspending fingolimod during temozolomide cycles.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Fingolimod
- Adenovirus types 4 and 7 live + Fingolimod Contraindicated
- Bcg vaccine live + Fingolimod Contraindicated
- Fingolimod + Pimozide Contraindicated
- Fingolimod + Ponesimod Contraindicated
- Fingolimod + Quinidine Contraindicated
- Fingolimod + Siponimod Contraindicated
Other interactions of Temozolomide
Frequently asked questions
Can I take Fingolimod with Temozolomide?
MediHelp rates the interaction as major. Fingolimod and Temozolomide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Temozolomide causes myelosuppression and lymphopenia, which add to fingolimod's lowering of lymphocytes. This may increase risk of infection, including opportunistic infections.
How serious is the interaction between Fingolimod and Temozolomide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; if used, monitor lymphocyte and neutrophil counts and consider infection prophylaxis per local practice. Consider suspending fingolimod during temozolomide cycles.
What other medicines interact with Fingolimod?
MediHelp also lists interactions of Fingolimod with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Pimozide. The full list is on the Fingolimod page.
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