Drug interactions
Deferiprone + Temozolomide
Severity: Major
Deferiprone and Temozolomide: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Temozolomide can cause myelosuppression, and deferiprone can cause agranulocytosis. Using them together raises the risk of severe neutropenia and infection.
What this interaction means in plain words
Deferiprone and Temozolomide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Deferiprone belongs to Miscellaneous; Temozolomide belongs to Oncology.
Why it happens
Additive bone marrow suppression.
What to do
Avoid concurrent use if possible. If needed, monitor absolute neutrophil counts more frequently and interrupt deferiprone if neutropenia develops.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Temozolomide
Other interactions of Deferiprone
- Clozapine + Deferiprone Contraindicated
- Abemaciclib + Deferiprone Major
- Acalabrutinib + Deferiprone Major
- Ado-trastuzumab emtansine + Deferiprone Major
- Ado-trastuzumab + Deferiprone Major
- Aldesleukin + Deferiprone Major
Frequently asked questions
Can I take Deferiprone with Temozolomide?
MediHelp rates the interaction as major. Deferiprone and Temozolomide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Temozolomide can cause myelosuppression, and deferiprone can cause agranulocytosis. Using them together raises the risk of severe neutropenia and infection.
How serious is the interaction between Deferiprone and Temozolomide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use if possible. If needed, monitor absolute neutrophil counts more frequently and interrupt deferiprone if neutropenia develops.
What other medicines interact with Temozolomide?
MediHelp also lists interactions of Temozolomide with, for example, Adenovirus types 4 and 7 live, Belatacept, Dengue vaccine. The full list is on the Temozolomide page.
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