Drug interactions
Temozolomide + Tofacitinib
Severity: Major
Temozolomide and Tofacitinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Temozolomide causes myelosuppression and lymphopenia, and tofacitinib also suppresses immune function and can lower lymphocyte and neutrophil counts. Together they increase the risk of serious infection, including opportunistic infections.
What this interaction means in plain words
Temozolomide and Tofacitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Temozolomide belongs to Oncology; Tofacitinib belongs to Musculoskeletal.
Why it happens
Additive immunosuppression and bone marrow suppression.
What to do
Avoid the combination if an alternative exists. If both are needed, monitor blood counts regularly and watch closely for infection.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Tofacitinib
- Baricitinib + Tofacitinib Contraindicated
- Cladribine + Tofacitinib Contraindicated
- Tofacitinib + Upadacitinib Contraindicated
- Abatacept + Tofacitinib Major
- Anti-thymocyte + Tofacitinib Major
- Antithymocyte globulin equine + Tofacitinib Major
Other interactions of Temozolomide
Frequently asked questions
Can I take Temozolomide with Tofacitinib?
MediHelp rates the interaction as major. Temozolomide and Tofacitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Temozolomide causes myelosuppression and lymphopenia, and tofacitinib also suppresses immune function and can lower lymphocyte and neutrophil counts. Together they increase the risk of serious infection, including opportunistic infections.
How serious is the interaction between Temozolomide and Tofacitinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if an alternative exists. If both are needed, monitor blood counts regularly and watch closely for infection.
What other medicines interact with Tofacitinib?
MediHelp also lists interactions of Tofacitinib with, for example, Baricitinib, Cladribine, Upadacitinib. The full list is on the Tofacitinib page.
Full monographs, dosing and an interaction checker in the MediHelp app
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