Drug interactions
Denosumab + Etrasimod
Severity: Moderate
Denosumab and Etrasimod: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can affect infection risk, and etrasimod lowers circulating lymphocytes. Combined use has not been studied, so additive infection risk is possible but unquantified.
What this interaction means in plain words
Denosumab and Etrasimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Denosumab belongs to Oncology; Etrasimod belongs to Gastrointestinal Tract.
Why it happens
Possible additive effects on infection risk: S1P receptor modulation reduces lymphocyte counts while denosumab inhibits RANKL signaling.
What to do
Monitor for signs of infection, especially skin and urinary infections, and review the need for both drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Denosumab
- Abatacept + Denosumab Moderate
- Adalimumab + Denosumab Moderate
- Alefacept + Denosumab Moderate
- Alemtuzumab + Denosumab Moderate
- Anakinra + Denosumab Moderate
- Azacitidine + Denosumab Moderate
Other interactions of Etrasimod
- Abatacept + Etrasimod Major
- Amiodarone + Etrasimod Major
- Anagrelide + Etrasimod Major
- Anakinra + Etrasimod Major
- Anti-thymocyte + Etrasimod Major
- Asenapine + Etrasimod Major
Frequently asked questions
Can I take Denosumab with Etrasimod?
MediHelp rates the interaction as moderate. Denosumab and Etrasimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can affect infection risk, and etrasimod lowers circulating lymphocytes. Combined use has not been studied, so additive infection risk is possible but unquantified.
How serious is the interaction between Denosumab and Etrasimod?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of infection, especially skin and urinary infections, and review the need for both drugs.
What other medicines interact with Denosumab?
MediHelp also lists interactions of Denosumab with, for example, Abatacept, Adalimumab, Alefacept. The full list is on the Denosumab page.
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