Drug interactions
Denosumab + Mechlorethamine
Severity: Moderate
Denosumab and Mechlorethamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mechlorethamine is an alkylating agent that causes myelosuppression and immune suppression when given systemically. Denosumab carries a labeled warning for serious infections in immunocompromised patients, so the infection risk may be additive. Topical mechlorethamine has little systemic exposure.
What this interaction means in plain words
Denosumab and Mechlorethamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Denosumab belongs to Oncology; Mechlorethamine belongs to Oncology.
Why it happens
Additive infection risk from alkylator-induced myelosuppression and possible immune effects of denosumab.
What to do
Monitor blood counts and watch for infection, especially with systemic mechlorethamine. Treat infections promptly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Denosumab and Mechlorethamine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Denosumab
- Abatacept + Denosumab Moderate
- Adalimumab + Denosumab Moderate
- Alefacept + Denosumab Moderate
- Alemtuzumab + Denosumab Moderate
- Anakinra + Denosumab Moderate
- Azacitidine + Denosumab Moderate
Other interactions of Mechlorethamine
Frequently asked questions
Can I take Denosumab with Mechlorethamine?
MediHelp rates the interaction as moderate. Denosumab and Mechlorethamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mechlorethamine is an alkylating agent that causes myelosuppression and immune suppression when given systemically. Denosumab carries a labeled warning for serious infections in immunocompromised patients, so the infection risk may be additive. Topical mechlorethamine has little systemic exposure.
How serious is the interaction between Denosumab and Mechlorethamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and watch for infection, especially with systemic mechlorethamine. Treat infections promptly.
What other medicines interact with Denosumab?
MediHelp also lists interactions of Denosumab with, for example, Abatacept, Adalimumab, Alefacept. The full list is on the Denosumab page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
