Drug interactions
Denosumab + Ofatumumab
Severity: Moderate
Denosumab and Ofatumumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ofatumumab depletes B-cells, which impairs humoral immunity and can lead to serious infections. Denosumab labeling cautions about infection risk in immunocompromised patients, so the two may add to risk.
What this interaction means in plain words
Denosumab and Ofatumumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Denosumab belongs to Oncology; Ofatumumab belongs to Miscellaneous.
Why it happens
Additive infection risk from CD20-mediated B-cell depletion and possible immune effects of denosumab.
What to do
Monitor for infection and screen for hepatitis B per ofatumumab labeling. Treat infections promptly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Denosumab
- Abatacept + Denosumab Moderate
- Adalimumab + Denosumab Moderate
- Alefacept + Denosumab Moderate
- Alemtuzumab + Denosumab Moderate
- Anakinra + Denosumab Moderate
- Azacitidine + Denosumab Moderate
Other interactions of Ofatumumab
- Fingolimod + Ofatumumab Major
- Lomustine + Ofatumumab Major
- Ofatumumab + Siponimod Major
Frequently asked questions
Can I take Denosumab with Ofatumumab?
MediHelp rates the interaction as moderate. Denosumab and Ofatumumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ofatumumab depletes B-cells, which impairs humoral immunity and can lead to serious infections. Denosumab labeling cautions about infection risk in immunocompromised patients, so the two may add to risk.
How serious is the interaction between Denosumab and Ofatumumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for infection and screen for hepatitis B per ofatumumab labeling. Treat infections promptly.
What other medicines interact with Denosumab?
MediHelp also lists interactions of Denosumab with, for example, Abatacept, Adalimumab, Alefacept. The full list is on the Denosumab page.
Full monographs, dosing and an interaction checker in the MediHelp app
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