Drug interactions
Lomustine + Ofatumumab
Severity: Major
Lomustine and Ofatumumab: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ofatumumab depletes B cells and lomustine suppresses bone marrow and immune function. Used together they may raise the risk of serious infections, including opportunistic infections and hepatitis B reactivation.
What this interaction means in plain words
Lomustine and Ofatumumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Lomustine belongs to Oncology; Ofatumumab belongs to Miscellaneous.
Why it happens
Additive immunosuppression through B-cell depletion and cytotoxic myelosuppression.
What to do
Avoid concurrent use where an alternative exists. If used together, monitor blood counts and infection signs, and screen for hepatitis B before ofatumumab.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Lomustine
- Adenovirus types 4 and 7 live + Lomustine Contraindicated
- Bcg vaccine live + Lomustine Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Lomustine Contraindicated
- Lomustine + Measles mumps and rubella vaccine Contraindicated
- Lomustine + Measles mumps and rubella vaccine live Contraindicated
- Lomustine + Measles mumps rubella and varicella vaccine live Contraindicated
Other interactions of Ofatumumab
- Fingolimod + Ofatumumab Major
- Ofatumumab + Siponimod Major
- Denosumab + Ofatumumab Moderate
Frequently asked questions
Can I take Lomustine with Ofatumumab?
MediHelp rates the interaction as major. Lomustine and Ofatumumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ofatumumab depletes B cells and lomustine suppresses bone marrow and immune function. Used together they may raise the risk of serious infections, including opportunistic infections and hepatitis B reactivation.
How serious is the interaction between Lomustine and Ofatumumab?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use where an alternative exists. If used together, monitor blood counts and infection signs, and screen for hepatitis B before ofatumumab.
What other medicines interact with Lomustine?
MediHelp also lists interactions of Lomustine with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Lomustine page.
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