Drug interactions
Denosumab + Pazopanib
Severity: Moderate
Denosumab and Pazopanib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pazopanib can cause neutropenia and infections, and denosumab has been associated with serious infections. Concurrent use may add to infection risk.
What this interaction means in plain words
Denosumab and Pazopanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Denosumab belongs to Oncology; Pazopanib belongs to Oncology.
Why it happens
Additive pharmacodynamic effect: kinase inhibitor-related myelosuppression combined with RANKL inhibition.
What to do
Monitor blood counts and clinically for infection. Treat infections early and adjust pazopanib per labeling if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Denosumab
- Abatacept + Denosumab Moderate
- Adalimumab + Denosumab Moderate
- Alefacept + Denosumab Moderate
- Alemtuzumab + Denosumab Moderate
- Anakinra + Denosumab Moderate
- Azacitidine + Denosumab Moderate
Other interactions of Pazopanib
- Adagrasib + Pazopanib Major
- Amiodarone + Pazopanib Major
- Amisulpride + Pazopanib Major
- Amobarbital + Pazopanib Major
- Anagrelide + Pazopanib Major
- Apalutamide + Pazopanib Major
Frequently asked questions
Can I take Denosumab with Pazopanib?
MediHelp rates the interaction as moderate. Denosumab and Pazopanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pazopanib can cause neutropenia and infections, and denosumab has been associated with serious infections. Concurrent use may add to infection risk.
How serious is the interaction between Denosumab and Pazopanib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and clinically for infection. Treat infections early and adjust pazopanib per labeling if needed.
What other medicines interact with Denosumab?
MediHelp also lists interactions of Denosumab with, for example, Abatacept, Adalimumab, Alefacept. The full list is on the Denosumab page.
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