Drug interactions
Denosumab + Ponesimod
Severity: Moderate
Denosumab and Ponesimod: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ponesimod lowers circulating lymphocytes and its effect persists after stopping, while denosumab has been linked to serious infections. Together they may increase infection risk.
What this interaction means in plain words
Denosumab and Ponesimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Denosumab belongs to Oncology; Ponesimod belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic effect: S1P receptor modulation sequesters lymphocytes while denosumab inhibits RANKL signalling in immune cells.
What to do
Monitor for infection and check lymphocyte counts when combined, including for some weeks after ponesimod is stopped. Treat infections promptly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Denosumab
- Abatacept + Denosumab Moderate
- Adalimumab + Denosumab Moderate
- Alefacept + Denosumab Moderate
- Alemtuzumab + Denosumab Moderate
- Anakinra + Denosumab Moderate
- Azacitidine + Denosumab Moderate
Other interactions of Ponesimod
- Fingolimod + Ponesimod Contraindicated
- Ponesimod + Siponimod Contraindicated
- Amiodarone + Ponesimod Major
- Amisulpride + Ponesimod Major
- Anagrelide + Ponesimod Major
- Anti-thymocyte + Ponesimod Major
Frequently asked questions
Can I take Denosumab with Ponesimod?
MediHelp rates the interaction as moderate. Denosumab and Ponesimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ponesimod lowers circulating lymphocytes and its effect persists after stopping, while denosumab has been linked to serious infections. Together they may increase infection risk.
How serious is the interaction between Denosumab and Ponesimod?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for infection and check lymphocyte counts when combined, including for some weeks after ponesimod is stopped. Treat infections promptly.
What other medicines interact with Denosumab?
MediHelp also lists interactions of Denosumab with, for example, Abatacept, Adalimumab, Alefacept. The full list is on the Denosumab page.
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