Drug interactions
Denosumab + Prednisolone
Severity: Moderate
Denosumab and Prednisolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Denosumab can raise the risk of serious infections, and concurrent immunosuppression with prednisolone may further increase this risk. This matters most for patients on long-term or high-dose steroids.
What this interaction means in plain words
Denosumab and Prednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Denosumab belongs to Oncology; Prednisolone belongs to Endocrine.
Why it happens
Additive immunosuppression, as denosumab modulates RANKL-related immune signaling and corticosteroids suppress immune function broadly.
What to do
Assess infection risk before starting and monitor for signs of infection, including skin infection. Ensure calcium and vitamin D are replete to avoid hypocalcemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prednisolone
- Bcg vaccine live + Prednisolone Contraindicated
- Measles mumps and rubella vaccine live + Prednisolone Contraindicated
- Measles mumps rubella and varicella vaccine live + Prednisolone Contraindicated
- Measles vaccine + Prednisolone Contraindicated
- Mifepristone + Prednisolone Contraindicated
- Prednisolone + Radium-223 dichloride Contraindicated
Other interactions of Denosumab
- Abatacept + Denosumab Moderate
- Adalimumab + Denosumab Moderate
- Alefacept + Denosumab Moderate
- Alemtuzumab + Denosumab Moderate
- Anakinra + Denosumab Moderate
- Azacitidine + Denosumab Moderate
Frequently asked questions
Can I take Denosumab with Prednisolone?
MediHelp rates the interaction as moderate. Denosumab and Prednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Denosumab can raise the risk of serious infections, and concurrent immunosuppression with prednisolone may further increase this risk. This matters most for patients on long-term or high-dose steroids.
How serious is the interaction between Denosumab and Prednisolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Assess infection risk before starting and monitor for signs of infection, including skin infection. Ensure calcium and vitamin D are replete to avoid hypocalcemia.
What other medicines interact with Prednisolone?
MediHelp also lists interactions of Prednisolone with, for example, Bcg vaccine live, Measles mumps and rubella vaccine live, Measles mumps rubella and varicella vaccine live. The full list is on the Prednisolone page.
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