Drug interactions
Denosumab + Sorafenib
Severity: Moderate
Denosumab and Sorafenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sorafenib can cause infections and lower blood counts, and denosumab is associated with serious infections. The combination may modestly increase infection risk.
What this interaction means in plain words
Denosumab and Sorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Denosumab belongs to Oncology; Sorafenib belongs to Oncology.
Why it happens
Additive pharmacodynamic effect: kinase inhibitor-related effects on immunity plus RANKL inhibition.
What to do
Monitor for infection and blood counts. Treat infections promptly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Denosumab
- Abatacept + Denosumab Moderate
- Adalimumab + Denosumab Moderate
- Alefacept + Denosumab Moderate
- Alemtuzumab + Denosumab Moderate
- Anakinra + Denosumab Moderate
- Azacitidine + Denosumab Moderate
Other interactions of Sorafenib
Frequently asked questions
Can I take Denosumab with Sorafenib?
MediHelp rates the interaction as moderate. Denosumab and Sorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sorafenib can cause infections and lower blood counts, and denosumab is associated with serious infections. The combination may modestly increase infection risk.
How serious is the interaction between Denosumab and Sorafenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for infection and blood counts. Treat infections promptly.
What other medicines interact with Denosumab?
MediHelp also lists interactions of Denosumab with, for example, Abatacept, Adalimumab, Alefacept. The full list is on the Denosumab page.
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