Drug interactions
Denosumab + Topotecan
Severity: Moderate
Denosumab and Topotecan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Topotecan is myelosuppressive and denosumab is associated with a higher rate of serious infections, including skin infections. Used together in a patient with chemotherapy-induced neutropenia, infection risk may be further increased.
What this interaction means in plain words
Denosumab and Topotecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Denosumab belongs to Oncology; Topotecan belongs to Oncology.
Why it happens
Additive pharmacodynamic effect on infection risk: denosumab inhibits RANKL signaling, which may affect immune function, while topotecan causes bone marrow suppression.
What to do
Monitor patients for signs of infection and follow neutrophil counts during topotecan cycles. Treat infections promptly and reassess the need for denosumab if serious infection develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Denosumab
- Abatacept + Denosumab Moderate
- Adalimumab + Denosumab Moderate
- Alefacept + Denosumab Moderate
- Alemtuzumab + Denosumab Moderate
- Anakinra + Denosumab Moderate
- Azacitidine + Denosumab Moderate
Other interactions of Topotecan
- Adenovirus types 4 and 7 live + Topotecan Contraindicated
- Amiodarone + Topotecan Major
- Cisplatin + Topotecan Major
- Cobicistat + Topotecan Major
- Cyclosporin + Topotecan Major
- Darunavir + Topotecan Major
Frequently asked questions
Can I take Denosumab with Topotecan?
MediHelp rates the interaction as moderate. Denosumab and Topotecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Topotecan is myelosuppressive and denosumab is associated with a higher rate of serious infections, including skin infections. Used together in a patient with chemotherapy-induced neutropenia, infection risk may be further increased.
How serious is the interaction between Denosumab and Topotecan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor patients for signs of infection and follow neutrophil counts during topotecan cycles. Treat infections promptly and reassess the need for denosumab if serious infection develops.
What other medicines interact with Denosumab?
MediHelp also lists interactions of Denosumab with, for example, Abatacept, Adalimumab, Alefacept. The full list is on the Denosumab page.
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