Drug interactions
Denosumab + Vincristine
Severity: Moderate
Denosumab and Vincristine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vincristine is mainly neurotoxic but can cause some myelosuppression and is used in regimens with other immunosuppressive drugs. Denosumab has been associated with serious infections, so the combination may add to infection risk in vulnerable patients.
What this interaction means in plain words
Denosumab and Vincristine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Denosumab belongs to Oncology; Vincristine belongs to Oncology.
Why it happens
Additive pharmacodynamic effect on infection risk: RANKL inhibition by denosumab may affect immune function in patients immunosuppressed by chemotherapy.
What to do
Monitor for signs of infection and follow blood counts per the chemotherapy protocol. Treat infections promptly and reassess denosumab if serious infection develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Denosumab
- Abatacept + Denosumab Moderate
- Adalimumab + Denosumab Moderate
- Alefacept + Denosumab Moderate
- Alemtuzumab + Denosumab Moderate
- Anakinra + Denosumab Moderate
- Azacitidine + Denosumab Moderate
Other interactions of Vincristine
- Adenovirus types 4 and 7 live + Vincristine Contraindicated
- Apalutamide + Vincristine Major
- Atazanavir + Vincristine Major
- Ceritinib + Vincristine Major
- Chloramphenicol + Vincristine Major
- Clarithromycin + Vincristine Major
Frequently asked questions
Can I take Denosumab with Vincristine?
MediHelp rates the interaction as moderate. Denosumab and Vincristine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vincristine is mainly neurotoxic but can cause some myelosuppression and is used in regimens with other immunosuppressive drugs. Denosumab has been associated with serious infections, so the combination may add to infection risk in vulnerable patients.
How serious is the interaction between Denosumab and Vincristine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of infection and follow blood counts per the chemotherapy protocol. Treat infections promptly and reassess denosumab if serious infection develops.
What other medicines interact with Denosumab?
MediHelp also lists interactions of Denosumab with, for example, Abatacept, Adalimumab, Alefacept. The full list is on the Denosumab page.
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