Drug interactions
Denosumab + Vinorelbine
Severity: Moderate
Denosumab and Vinorelbine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vinorelbine commonly causes neutropenia, and denosumab has been associated with serious infections. Combined use may increase infection risk in patients with cancer.
What this interaction means in plain words
Denosumab and Vinorelbine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Denosumab belongs to Oncology; Vinorelbine belongs to Oncology.
Why it happens
Additive pharmacodynamic effect on infection risk: RANKL inhibition by denosumab may affect immune function while vinorelbine suppresses bone marrow.
What to do
Monitor neutrophil counts and clinical signs of infection during therapy. Treat infections promptly and reassess denosumab if serious infection develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Denosumab and Vinorelbine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Denosumab
- Abatacept + Denosumab Moderate
- Adalimumab + Denosumab Moderate
- Alefacept + Denosumab Moderate
- Alemtuzumab + Denosumab Moderate
- Anakinra + Denosumab Moderate
- Azacitidine + Denosumab Moderate
Other interactions of Vinorelbine
Frequently asked questions
Can I take Denosumab with Vinorelbine?
MediHelp rates the interaction as moderate. Denosumab and Vinorelbine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vinorelbine commonly causes neutropenia, and denosumab has been associated with serious infections. Combined use may increase infection risk in patients with cancer.
How serious is the interaction between Denosumab and Vinorelbine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor neutrophil counts and clinical signs of infection during therapy. Treat infections promptly and reassess denosumab if serious infection develops.
What other medicines interact with Denosumab?
MediHelp also lists interactions of Denosumab with, for example, Abatacept, Adalimumab, Alefacept. The full list is on the Denosumab page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
