Drug interactions
Desflurane + Dosulepin
Severity: Moderate
Desflurane and Dosulepin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dosulepin is a sedating tricyclic antidepressant that may add to CNS depression from desflurane. Tricyclics can also contribute to arrhythmias and hypotension during general anesthesia.
What this interaction means in plain words
Desflurane and Dosulepin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Desflurane belongs to Central Nervous System; Dosulepin belongs to Central Nervous System.
Why it happens
Additive CNS depression plus tricyclic anticholinergic, alpha-blocking and cardiac conduction effects that may combine with volatile anesthetic cardiovascular effects.
What to do
Inform the anesthesia team of tricyclic use and monitor ECG and blood pressure intraoperatively. Titrate the anesthetic carefully and watch for delayed emergence.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desflurane
Other interactions of Dosulepin
- Dosulepin + Isocarboxazid Contraindicated
- Dosulepin + Phenelzine Contraindicated
- Dosulepin + Thioridazine Contraindicated
- Dosulepin + Tranylcypromine Contraindicated
- Amitriptyline + Dosulepin Major
- Buprenorphine + Dosulepin Major
Frequently asked questions
Can I take Desflurane with Dosulepin?
MediHelp rates the interaction as moderate. Desflurane and Dosulepin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dosulepin is a sedating tricyclic antidepressant that may add to CNS depression from desflurane. Tricyclics can also contribute to arrhythmias and hypotension during general anesthesia.
How serious is the interaction between Desflurane and Dosulepin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Inform the anesthesia team of tricyclic use and monitor ECG and blood pressure intraoperatively. Titrate the anesthetic carefully and watch for delayed emergence.
What other medicines interact with Desflurane?
MediHelp also lists interactions of Desflurane with, for example, Amisulpride, Anagrelide, Arsenic trioxide. The full list is on the Desflurane page.
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