Drug interactions
Desflurane + Entrectinib
Severity: Moderate
Desflurane and Entrectinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Entrectinib is associated with QT prolongation, and volatile anesthetics such as desflurane can lengthen QT too. Combined use may increase the risk of torsades de pointes.
What this interaction means in plain words
Desflurane and Entrectinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Desflurane belongs to Central Nervous System; Entrectinib belongs to Oncology.
Why it happens
Additive prolongation of ventricular repolarization.
What to do
Review baseline QTc and electrolytes before the procedure and monitor the ECG perioperatively. Consider an alternative anesthetic technique if QTc is substantially prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desflurane
Other interactions of Entrectinib
Frequently asked questions
Can I take Desflurane with Entrectinib?
MediHelp rates the interaction as moderate. Desflurane and Entrectinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Entrectinib is associated with QT prolongation, and volatile anesthetics such as desflurane can lengthen QT too. Combined use may increase the risk of torsades de pointes.
How serious is the interaction between Desflurane and Entrectinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Review baseline QTc and electrolytes before the procedure and monitor the ECG perioperatively. Consider an alternative anesthetic technique if QTc is substantially prolonged.
What other medicines interact with Desflurane?
MediHelp also lists interactions of Desflurane with, for example, Amisulpride, Anagrelide, Arsenic trioxide. The full list is on the Desflurane page.
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