Drug interactions
Desflurane + Ganaxolone
Severity: Moderate
Desflurane and Ganaxolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ganaxolone is a neuroactive steroid that causes somnolence and sedation. Combined with desflurane it may increase sedation and prolong recovery from anesthesia.
What this interaction means in plain words
Desflurane and Ganaxolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Desflurane belongs to Central Nervous System; Ganaxolone belongs to Central Nervous System.
Why it happens
Additive CNS depression via positive modulation of GABA-A receptors by both drugs.
What to do
Titrate desflurane to depth-of-anesthesia monitoring and anticipate a reduced requirement. Monitor respiratory status and the time to emergence.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Desflurane and Ganaxolone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Desflurane
Other interactions of Ganaxolone
Frequently asked questions
Can I take Desflurane with Ganaxolone?
MediHelp rates the interaction as moderate. Desflurane and Ganaxolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ganaxolone is a neuroactive steroid that causes somnolence and sedation. Combined with desflurane it may increase sedation and prolong recovery from anesthesia.
How serious is the interaction between Desflurane and Ganaxolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate desflurane to depth-of-anesthesia monitoring and anticipate a reduced requirement. Monitor respiratory status and the time to emergence.
What other medicines interact with Desflurane?
MediHelp also lists interactions of Desflurane with, for example, Amisulpride, Anagrelide, Arsenic trioxide. The full list is on the Desflurane page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
