Drug interactions
Desflurane + Glasdegib
Severity: Moderate
Desflurane and Glasdegib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glasdegib can prolong the QT interval, and desflurane may add to the effect. The combination can increase the risk of torsades de pointes.
What this interaction means in plain words
Desflurane and Glasdegib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Desflurane belongs to Central Nervous System; Glasdegib belongs to Oncology.
Why it happens
Additive QT prolongation; predicted from the individual effects.
What to do
Obtain a baseline ECG and correct electrolytes before anesthesia. Monitor the ECG perioperatively.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desflurane
Other interactions of Glasdegib
- Amiodarone + Glasdegib Major
- Amisulpride + Glasdegib Major
- Amobarbital + Glasdegib Major
- Anagrelide + Glasdegib Major
- Apalutamide + Glasdegib Major
- Asenapine + Glasdegib Major
Frequently asked questions
Can I take Desflurane with Glasdegib?
MediHelp rates the interaction as moderate. Desflurane and Glasdegib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Glasdegib can prolong the QT interval, and desflurane may add to the effect. The combination can increase the risk of torsades de pointes.
How serious is the interaction between Desflurane and Glasdegib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct electrolytes before anesthesia. Monitor the ECG perioperatively.
What other medicines interact with Desflurane?
MediHelp also lists interactions of Desflurane with, for example, Amisulpride, Anagrelide, Arsenic trioxide. The full list is on the Desflurane page.
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