Drug interactions
Desflurane + Lefamulin
Severity: Moderate
Desflurane and Lefamulin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lefamulin can prolong the QT interval, particularly with intravenous dosing, and desflurane may add to this. The combination increases the risk of torsades de pointes in susceptible patients.
What this interaction means in plain words
Desflurane and Lefamulin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Desflurane belongs to Central Nervous System; Lefamulin belongs to Anti Bacterial.
Why it happens
Additive prolongation of cardiac repolarization.
What to do
Check baseline QTc and correct potassium and magnesium before anesthesia. Monitor the ECG perioperatively or consider an alternative antibiotic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desflurane
Other interactions of Lefamulin
- Lefamulin + Methadone Contraindicated
- Lefamulin + Pimavanserin Contraindicated
- Lefamulin + Pimozide Contraindicated
- Lefamulin + Quinidine Contraindicated
- Alfuzosin + Lefamulin Major
- Amiodarone + Lefamulin Major
Frequently asked questions
Can I take Desflurane with Lefamulin?
MediHelp rates the interaction as moderate. Desflurane and Lefamulin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lefamulin can prolong the QT interval, particularly with intravenous dosing, and desflurane may add to this. The combination increases the risk of torsades de pointes in susceptible patients.
How serious is the interaction between Desflurane and Lefamulin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline QTc and correct potassium and magnesium before anesthesia. Monitor the ECG perioperatively or consider an alternative antibiotic.
What other medicines interact with Desflurane?
MediHelp also lists interactions of Desflurane with, for example, Amisulpride, Anagrelide, Arsenic trioxide. The full list is on the Desflurane page.
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